RECENT ADVANCE IN CANCER RESEARCH——The Discovery of the Physiological Barriers
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摘要: 近年来发明的生物疗法,如单克隆抗体(Mabs),增长因子(GFs)等,由于它们在体外对癌细胞有效的杀伤能力而被称为“突破性药物”,“神奇炮弹”.但当这些药物用于病人体内时则疗效较差.从事肿瘤结构研究达15年之久的Jain博士最近指出,药物在体内疗效不好的原因是肿瘤内部产生了三个生理屏障:①非均匀的血液供给;②组织间隙中的高压;③组织间隙中的大传质距离.这些屏障使药物很难到达肿瘤内核区.尤其是对于从人体免疫系统提取的象单克隆抗体这类药物更严重,因为免疫系统的细胞和分子比一般药物分子大得多.因此,要使治癌药物在体内完成预期医疗效果,必须发展克服生理屏障的方法. 本文对生理屏障进行了全面描述,希望引起我国癌症研究者的注意和生物力学工作者的兴趣.Abstract: The newly designed, highly touted biological therapies like monoclonal antibodies (Mabs) , lymphokine activated killer cells (LAK) , growth factors (GFs) and so forth, because of their potent toxicity to cancer cells in vitro, have often been heralded as "breakthrough drugs" or "magic bullets" . But these drugs do not always produce good results when applied to patients. Dr. Jain, who has been studying tumor structures for 15 years, recently, found that the doomed failure of these drugs is due to the fact t...
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